Humoral Immune Status in Relation to Outcomes in Patients with Idiopathic Pulmonary Fibrosis.
Thijs W HoffmanC H M van MoorselK M KazemierD H BiesmaJ C GruttersD A van KesselPublished in: Lung (2021)
The prevalence of humoral immunodeficiencies was low in patients with IPF and not associated with AE-IPF or survival. Elevated lymphocytes in BAL were associated with the development of AE-IPF and worse survival. Higher serum immunoglobulins and immune cells in blood were also associated with worse survival. The local immune response in the lungs may be a target for future therapies.