Targeted Molecular Profiling of Circulating Cell-Free DNA in Patients With Advanced Hepatocellular Carcinoma.
Darren CowzerJessica B WhiteJoanne F ChouPin-Jung ChenTae-Hyung KimDanny N KhalilImane H El DikaKatrina ColumnaAmin YaqubieJoseph S LightJinru ShiaHooman YarmohammadiJoseph Patrick ErinjeriAlice C WeiWilliam R JarnaginRichard Kinh Gian DoDavid B SolitMarinela CapanuRonak H ShahMichael F BergerGhassan K Abou-AlfaJames J HardingPublished in: JCO precision oncology (2023)
Tumor mutation profiling of cfDNA in HCC represents an alternative to tissue-based genomic profiling, given the high degree of tumor-plasma NGS concordance; however, genotyping of both blood and tumor may be required to detect all clinically actionable genomic alterations.