The effect of acute intradermal administration of ascorbate on heat loss responses in older adults with uncomplicated controlled hypertension.
Naoto FujiiRobert D MeadeMadison D SchmidtKelli E KingPierre BoulayMarcel RuzickaTatsuro AmanoGlen P KennyPublished in: Experimental physiology (2022)
-nitro-l-arginine methyl ester (l-NAME), a non-selective NOS inhibitor, or (4) a combination of ascorbate and l-NAME. Relative to Control, no effect of ascorbate was observed on CVC or sweating in either group (P = 0.619). However, l-NAME reduced CVC relative to Control in both groups (P ≤ 0.038). No effect of any treatment on sweating was observed (P ≥ 0.306). Thus, acute local administration of ascorbate to forearm skin does not enhance the activation of heat loss responses of cutaneous vasodilatation and sweating in older adults, and those with hypertension during an exercise-heat stress.
Keyphrases
- heat stress
- liver failure
- blood pressure
- physical activity
- respiratory failure
- heat shock
- drug induced
- aortic dissection
- nitric oxide
- hepatitis b virus
- high intensity
- soft tissue
- nitric oxide synthase
- community dwelling
- middle aged
- intensive care unit
- combination therapy
- extracorporeal membrane oxygenation
- urinary tract infection
- amino acid
- wound healing
- mechanical ventilation