Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing.

Martee L HensleyShweta S ChavanDavid B SolitRajmohan MuraliRobert SoslowSarah ChiangAchim A JungbluthChaitanya BandlamudiPreethi SrinivasanWilliam D TapEvan RosenbaumBarry S TaylorMark T A DonoghueDavid M Hyman

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Prospective genomic profiling can contribute to diagnostic precision and inform treatment selection in patients with uterine sarcomas. There was evidence of clinical benefit in patients with uterine leiomyosarcoma with somatic BRCA2 alterations treated with PARP inhibitors.

Keyphrases

single cell
copy number
high grade
dna damage
dna methylation
replacement therapy