Acquired Cross-resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC paralogs.

Shreoshi Pal Choudhuri Luc Girard Jun Yi Stanley Lim Jillian F WiseBraeden FreitasDi Yang Edmond Wong Seth Hamilton Victor D Chien Collin Gilbreath Jun Zhong Sarah PhatDavid T MyersCamilla L ChristensenMarcello Stanzione Kwok-Kin Wong Anna F Farago Catherine B Meador Nicholas J Dyson Michael S Lawrence Sihan Wu Benjamin J Drapkin

Published in: bioRxiv : the preprint server for biology (2023)

paralogs on ecDNA are recurrent drivers of acquired cross-resistance in SCLC.

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