Evidence for the synthesis of an unusual high spin (S = 7/2) [Cu-3Fe-4S] cluster in the radical-SAM enzyme RSAD2 (viperin).

Kourosh Honarmand EbrahimiC SilveiraSmilja Todorovic

Published in: Chemical communications (Cambridge, England) (2018)

We demonstrate the synthesis and spectroscopic characterization of an unusual high spin (S = 7/2) [Cu-3Fe-4S] cluster in a member of the radical-SAM enzymes. This is the first step in using synthetic [Me-3Fe-4S] clusters for obtaining new insight into the mechanism of radical-SAM catalysis.

Keyphrases

metal organic framework
aqueous solution
room temperature
density functional theory
visible light
single molecule
molecular docking
molecular dynamics