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Long-Term Outcome Following Treatment With Allogeneic Mesenchymal Stem/Stromal Cells for Radiation-Induced Hyposalivation and Xerostomia.

Kathrine Kronberg JakobsenCharlotte Duch LynggaardNatasja PaaskeAmanda-Louise Fenger CarlanderJens KastrupAnne Werner HaugeRobin ChristensenChristian GrønhøjChristian von Buchwald
Published in: Stem cells translational medicine (2024)
In conclusion, this study is the first to present long-term follow-up outcomes of allogeneic ASC treatment as a therapeutic option for radiation-induced xerostomia. The study found that ASC treatment appears safe, and there were no indications of adverse immune responses at the 3-year follow-up. Further studies are warranted to evaluate the findings in larger settings.
Keyphrases
  • radiation induced
  • immune response
  • bone marrow
  • radiation therapy
  • stem cell transplantation
  • stem cells
  • emergency department
  • low dose
  • nlrp inflammasome
  • insulin resistance