New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells.
Denis N ChausovDmitriy E BurmistrovAlexander D KurilovNikolay F BunkinMaxim E AstashevAlexander V SimakinMaria V VedunovaSergey V GudkovPublished in: Materials (Basel, Switzerland) (2021)
The present study a comprehensive analysis of the antibacterial properties of a composite material based on borosiloxane and zinc oxide nanoparticles (ZnO NPs). The effect of the polymer matrix and ZnO NPs on the generation of reactive oxygen species, hydroxyl radicals, and long-lived oxidized forms of biomolecules has been studied. All variants of the composites significantly inhibited the division of E. coli bacteria and caused them to detach from the substrate. It was revealed that the surfaces of a composite material based on borosiloxane and ZnO NPs do not inhibit the growth and division of mammalians cells. It is shown in the work that the positive effect of the incorporation of ZnO NPs into borosiloxane can reach 100% or more, provided that the viscoelastic properties of borosiloxane with nanoparticles are retained.
Keyphrases
- oxide nanoparticles
- induced apoptosis
- room temperature
- reduced graphene oxide
- quantum dots
- cell cycle arrest
- reactive oxygen species
- visible light
- escherichia coli
- endoplasmic reticulum stress
- oxidative stress
- gene expression
- cystic fibrosis
- light emitting
- cell proliferation
- pseudomonas aeruginosa
- biofilm formation
- single molecule
- wound healing
- amino acid