Microdialysis in awake macaque monkeys for central nervous system pharmacokinetics.

Thibaud ThiollierCaisheng WuGregory PorrasErwan BezardQin LiJinlan ZhangHugues Contamin

Published in: Animal models and experimental medicine (2018)

Data suggest that brain microdialysis in vigil macaque monkey, the species of choice for classic pharmacokinetic/pharmacodynamics studies could help predicting human brain bioavailability of a small molecule depending on the protein involved in the efflux transport from the brain.

Keyphrases

small molecule
resting state
white matter
protein protein
functional connectivity
cerebral ischemia
electronic health record
big data
deep brain stimulation
amino acid
binding protein
decision making
genetic diversity
artificial intelligence
data analysis