Azithromycin enhances anticancer activity of TRAIL by inhibiting autophagy and up-regulating the protein levels of DR4/5 in colon cancer cells in vitro and in vivo.

Xinran QiaoXiaofei WangYue ShangYi LiShu-Zhen Chen

Published in: Cancer communications (London, England) (2018)

The synergistic antitumor effect of azithromycin and TRAIL mainly relies on the up-regulations of DR4 and DR5, which in turn result from LC-3B-involved autophagy inhibition.

Keyphrases

editorial comment
signaling pathway
cell death
endoplasmic reticulum stress
oxidative stress
mass spectrometry
fluorescent probe
protein protein
simultaneous determination
living cells
sensitive detection
amino acid
binding protein
high resolution
solid phase extraction