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RAD51 wrestles with SUMO.

Younghoon KeeJung-Hee LeeHo Jin You
Published in: Molecular & cellular oncology (2022)
RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. ATM/ATR-induced phosphorylation of TOPORS is necessary for this event, revealing a new role of these master DNA damage response kinases in HR repair.
Keyphrases
  • dna repair
  • dna damage response
  • dna damage
  • oxidative stress
  • gene expression
  • high glucose
  • diabetic rats
  • transcription factor
  • protein kinase
  • dna methylation