Prebiotic fibre mixtures counteract the manifestation of gut microbial dysbiosis induced by the chemotherapeutic 5-Fluorouracil (5-FU) in a validated in vitro model of the colon.
Janine ZiemonsLars E HillegeRomy AarnoutseJudith De Vos-GeelenLiselot Valkenburg-van IerselJasper MastenbroekRobin M J M van GeelDavid J M BarnettSander S RensenArdy van HelvoortLotte H J DopheideGuus RoeselersJohn PendersMarjolein L SmidtKoen VenemaPublished in: BMC microbiology (2024)
These data suggest that prebiotic fibre mixtures represent a promising strategy to modulate 5-FU-induced microbial dysbiosis towards a more favourable microbiota, thereby possibly improving 5-FU efficacy and reducing toxicity, which should be evaluated further in clinical studies.