Oleanolic Acid (OA) Targeting UNC5B Inhibits Proliferation and EMT of Ovarian Cancer Cell and Increases Chemotherapy Sensitivity of Niraparib.

Zhen ZengJing YuZhongqing Jiang Ningwei Zhao

Published in: Journal of oncology (2022)

UNC5B acts as an oncogenic gene in ovarian cancer. OA inhibits ovarian cancer cell proliferation, migration, and EMT by targeting UNC5B and increases the antitumor effect of niraparib. UNC5B is expected to be a new potential therapeutic target for ovarian cancer. OA may be used as an antitumor drug and deserves further study.

Keyphrases

cell proliferation
knee osteoarthritis
epithelial mesenchymal transition
transcription factor
cell cycle
copy number
squamous cell carcinoma
risk assessment
radiation therapy
signaling pathway
adverse drug
drug delivery
pi k akt
rectal cancer