The role of neoadjuvant chemotherapy in the management of metastatic central nervous system germinoma: A meta-analysis.

Mohammad H Abu ArjaMargaret S ShataraM Fatih OkcuSusan L McGovernJack M SuMohamed S Abdelbaki

Published in: Pediatric blood & cancer (2023)

Our analysis does not support avoiding spinal irradiation among patients with radiographic metastatic CNS germinoma. Future studies are needed to confirm whether neoadjuvant chemotherapy will allow a reduction of irradiation dose without compromising survival.

Keyphrases

neoadjuvant chemotherapy
locally advanced
squamous cell carcinoma
small cell lung cancer
lymph node
sentinel lymph node
spinal cord
blood brain barrier
radiation induced
current status
cerebrospinal fluid
case control
early stage
spinal cord injury