Variations in Trim5α and Cyclophilin A genes among HIV-1 elite controllers and non controllers in Uganda: a laboratory-based cross-sectional study.

Sharon Bright AmanyaBrian NyiroFrancis WaswaBonniface OburaRebecca NakazibaEva NabulimeAshaba Fred KatabaziRose NabatanziAlice BayiyanaGerald MboowaAlex KayongoMisaki WayengeraObondo James Sande

Published in: Retrovirology (2020)

Variations in TRIM5α and Cyclophillin A promoter may influence HIV viral suppression. The rs10838525 SNP in TRIM5α may contribute to viral suppression among HIV-1 elite controllers. The rs6850 in the cyclophillin A gene may be responsible for HIV-1 rapid progression among HIV-1 non-controllers. These SNPs should be investigated mechanistically to determine their precise role in HIV-1 viral suppression.

Keyphrases

antiretroviral therapy
hiv positive
hiv infected
hiv testing
human immunodeficiency virus
hepatitis c virus
hiv aids
men who have sex with men
genome wide
sars cov
south africa
dna methylation
mass spectrometry
copy number
quantum dots