Stimulated PBMC-produced IFN-γ and TNF-α are associated with altered relapse risk in multiple sclerosis: results from a prospective cohort study.

Steve Simpson YapNiall StewartIngrid van der MeiPetr OtahalJac CharlesworthAnne-Louise PonsonbyLeigh BlizzardTerence DwyerFotini PittasPeter GiesBruce Taylor

Published in: Journal of neurology, neurosurgery, and psychiatry (2014)

We found strong effects of IFN-γ and TNF-α on relapse risk, these differing by immunomodulatory therapy, season, and serum vitamin D, as well as by genotype. These results indicate altered reactivity of immune cells modulate MS disease.

Keyphrases

multiple sclerosis
rheumatoid arthritis
immune response
dendritic cells
mass spectrometry
ms ms
white matter
mesenchymal stem cells
cell therapy
breast cancer risk