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Stimulated PBMC-produced IFN-γ and TNF-α are associated with altered relapse risk in multiple sclerosis: results from a prospective cohort study.

Steve Simpson YapNiall StewartIngrid van der MeiPetr OtahalJac CharlesworthAnne-Louise PonsonbyLeigh BlizzardTerence DwyerFotini PittasPeter GiesBruce Taylor
Published in: Journal of neurology, neurosurgery, and psychiatry (2014)
We found strong effects of IFN-γ and TNF-α on relapse risk, these differing by immunomodulatory therapy, season, and serum vitamin D, as well as by genotype. These results indicate altered reactivity of immune cells modulate MS disease.
Keyphrases
  • multiple sclerosis
  • rheumatoid arthritis
  • immune response
  • dendritic cells
  • mass spectrometry
  • ms ms
  • white matter
  • mesenchymal stem cells
  • cell therapy
  • breast cancer risk