Novel Associations of BST1 and LAMP3 With REM Sleep Behavior Disorder.
Kheireddin MuftiEric YuUladzislau RudakouLynne KrohnJennifer A RuskeyFarnaz AsayeshSandra B LaurentDan SpiegelmanIsabelle ArnulfMichele T M HuJacques Y MontplaisirJean-François GagnonAlex DesautelsYves DauvilliersGian Luigi GigliMariarosaria ValenteFrancesco JanesAndrea BernardiniBirgit HöglAmbra StefaniEvi HolzknechtKarel SonkaDavid KemlinkWolfgang Hermann OertelAnnette JanzenGiuseppe PlazziElena AntelmiMichela FigorilliMonica PulighedduBrit MollenhauerClaudia TrenkwalderFriederike Sixel-DöringValérie Cochen De CockChristelle Charley MonacaAnna HeidbrederLuigi Ferini-StrambiFemke DijkstraMineke ViaeneBeatriz AbrilBradley F BoeveJean-François TrempeGuy A RouleauRonald B PostumaZiv Gan-OrPublished in: Neurology (2021)
Our results suggest that rare coding variants in BST1 and rare noncoding variants in LAMP3 are associated with iRBD. Additional studies are required to replicate these results and to examine whether loss of function of BST1 could be a therapeutic target.