Sirt3 restricts tumor initiation via promoting LONP1 deacetylation and K63 ubiquitination.

Liyi WuXinyi YanRuibo SunYe MaWanyu YaoBaogui GaoQingyuan ZhangJunxiong YouHao WangQinrui HanXue-Gang Sun

Published in: Journal of translational medicine (2023)

Sirt3 represents a targetable metabolic checkpoint of oncogenesis, which produces energy restriction effects via maintaining LONP1 K145 deacetylation and subsequent K63 ubiquitination.

Keyphrases

oxidative stress
ischemia reperfusion injury
dna damage
cell cycle