Synthesis and structure-activity relationship study of diaryl[d,f][1,3]diazepines as potential anti-cancer agents.
Longjia YanHui WangYunpeng ChenZhiwei LiYazhong PeiPublished in: Molecular diversity (2018)
We herein report the synthesis, biological activity and preliminary structure-activity relationships of a series of diaryl[1,3]diazepines. These compounds were able to inhibit the proliferation of many cancer cell lines, such as HeLa, MCF-7, SGC7901 and A549. When HeLa cells were treated with lead compounds 7j and 7k at 3 [Formula: see text] concentration, cell arrest was observed in the G2/M phase.
Keyphrases
- cell cycle arrest
- structure activity relationship
- cell death
- induced apoptosis
- signaling pathway
- papillary thyroid
- pi k akt
- single cell
- cell therapy
- cell cycle
- squamous cell
- smoking cessation
- squamous cell carcinoma
- human milk
- endoplasmic reticulum stress
- stem cells
- human health
- risk assessment
- young adults
- low birth weight