Stress signalling and STAT1 activation characterize the keratinocytic gene expression pattern in Hidradenitis suppurativa.

Verena Gerlinde Frings L Jopp Mugdha Srivastava D Presser Matthias Goebeler Marc Schmidt

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2022)

Our data implicate a key role of stress signalling and JAK/STAT1 activation in disease progression of HS and suggest interference with JAK/STAT1 signalling as a potentially promising therapeutic approach for HS.

Keyphrases

gene expression
hidradenitis suppurativa
dna methylation
stress induced
cell proliferation
electronic health record
machine learning
heat stress
artificial intelligence