Self-Assembling Metallocomplexes of the Amphiphilic 1,4-Diazabicyclo[2.2.2]octane Derivative as a Platform for the Development of Nonplatinum Anticancer Drugs.
Lucia Ya ZakharovaAlexandra D VoloshinaMarina R IbatullinaElena P ZhiltsovaSvetlana S LukashenkoDarya A KuznetsovaMarianna P KutyrevaAnastasiia S SapunovaAnna A KufelkinaNatalia V KulikOlga N KataevaKamil A IvshinAidar T GubaidullinVadim V SalnikovIrek R NizameevMarsil K KadirovOleg G SinyashinPublished in: ACS omega (2022)
New 1-cetyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide complexes with copper(II) bromide and lanthanum(III) nitrate were characterized using dynamic light scattering and transmission electron microscopy, with self-assembly and the morphological behavior elucidated. For the lanthanum(III) nitrate complex, the 3D crystal structure was characterized using X-ray diffractometry. These metallosurfactants were tested as antitumor agents, and a high cytotoxic effect comparable with doxorubicin was revealed against the M-HeLa and A-549 cell lines. Both complexes were 2 times more active toward the MCF-7 cell line than the breast cancer drug tamoxifen. The cytotoxic mechanism of complexes is assumed to be related to the induction of apoptosis through the mitochondrial pathway.
Keyphrases
- electron microscopy
- crystal structure
- oxidative stress
- nitric oxide
- cell cycle arrest
- breast cancer cells
- drinking water
- cell death
- high resolution
- drug delivery
- endoplasmic reticulum stress
- drug induced
- magnetic resonance
- young adults
- computed tomography
- cell proliferation
- signaling pathway
- positive breast cancer
- water soluble
- breast cancer risk