Inhibiting ALK2/ALK3 Signaling to Differentiate and Chemo-Sensitize Medulloblastoma.

Doria FilipponiMarina Pagnuzzi-BoncompagniGilles Pagès

Published in: Cancers (2022)

Our work suggests that interfering with the BMP4 signaling pathway impaired the maintenance of the CSC pool by promoting cell differentiation. Hence, differentiation therapy might represent an innovative therapeutic to improve the current standard of care in MB patients.

Keyphrases

signaling pathway
end stage renal disease
ejection fraction
newly diagnosed
advanced non small cell lung cancer
palliative care
prognostic factors
photodynamic therapy
pi k akt
peritoneal dialysis
stem cells
radiation therapy
drug delivery
locally advanced
chronic pain
rectal cancer