Comprehensive Molecular Analysis of Inflammatory Myofibroblastic Tumors Reveals Diverse Genomic Landscape and Potential Predictive Markers for Response to Crizotinib.

Che-Jui Lee Patrick Schöffski Elodie Modave J Tom van WezelBram BoeckxJozef SufliarskyAndré B P van Kuilenburg Jean Yves Blay Maria Debiec-Rychter Raf M E Sciot Judith V M G Bovée Diether LambrechtsAgnieszka Wozniak

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

We identified multiple genetic alterations in archival IMFT material and provide further insight into the molecular profile of this ultra-rare, heterogeneous malignancy, which may potentially translate into novel treatment approaches for this orphan disease.

Keyphrases

copy number
genome wide
high resolution
advanced non small cell lung cancer
gene expression
dna methylation
climate change
replacement therapy
epidermal growth factor receptor