Clinical, biochemical and genetic findings in adult patients with chronic hypophosphatasemia.
V GuarnieriF SileriRita IndirliG GuabelloM LonghiG DitoC VerdelliSabrina CorbettaPublished in: Journal of endocrinological investigation (2021)
In osteopenic/osteoporotic patients, single clinical or biochemical factors did not distinguish hypophosphatasemic patients harboring pALPL or bALPL from those harboring wtALPL. Occurrence of multiple clinical and biochemical features is predictive of ALPL anomalies, and, therefore, they should be carefully identified. Tamoxifen emerged as a hypophosphatasemic drug.