Regenerative Effects of Exosomes-Derived MSCs: An Overview on Spinal Cord Injury Experimental Studies.
Giovanni SchepiciSerena SilvestroEmanuela MazzonPublished in: Biomedicines (2023)
Spinal cord injury (SCI) is a devastating condition usually induced by the initial mechanical insult that can lead to permanent motor and sensory deficits. At present, researchers are investigating potential therapeutic strategies to ameliorate the neuro-inflammatory cascade that occurs post-injury. Although the use of mesenchymal stromal/stem (MSCs) as a potential therapy in application to regenerative medicine promoted anti-inflammatory and neuroprotective effects, several disadvantages limit their use. Therefore, recent studies have reported the effects of exosomes-derived MSCs (MSC-EXOs) as an innovative therapeutic option for SCI patients. It is noteworthy that MSC-EXOs can maintain the integrity of the blood-spinal cord barrier (BSCB), promoting angiogenic, proliferative, and anti-oxidant effects, as well as immunomodulatory, anti-inflammatory, and antiapoptotic properties. Therefore, in this study, we summarized the preclinical studies reported in the literature that have shown the effects of MSC-EXOs as a new molecular target to counteract the devastating effects of SCI.
Keyphrases
- spinal cord injury
- mesenchymal stem cells
- spinal cord
- anti inflammatory
- bone marrow
- umbilical cord
- stem cells
- neuropathic pain
- cell therapy
- case control
- end stage renal disease
- ejection fraction
- systematic review
- newly diagnosed
- chronic kidney disease
- oxidative stress
- traumatic brain injury
- prognostic factors
- human health
- smoking cessation