The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo.

Sarah WeberSebastian E KoschadeChristopher M HoffmannTaronish D DubashKlara M GiesslerSebastian M DieterFriederike HerbstHanno GlimmClaudia R Ball

Published in: BMC cancer (2019)

These results suggest that HEYL negatively regulates metastasis formation in vivo presumably by inhibiting intravasation of metastasis-initiating cells.

Keyphrases

induced apoptosis
cell cycle arrest
cell proliferation
oxidative stress
cell death
genome wide
dna methylation
copy number