Cellular Bone Matrix in Spine Surgery - Are They Worth the Risk: A Systematic Review.

Mark J Lambrechts Tariq Ziad IssaAditya MazmudarYunsoo A Lee Gregory R Toci Nicholas D D'AntonioMeghan SchilkenKenneth LingenfelterChristopher K KeplerGregory D SchroederAlexander R Vaccaro

Published in: Global spine journal (2023)

Current evidence regarding the use of cellular bone matrix as an osteobiologic during spine surgery is weak and limited to low-grade non-comparative studies subject to industry funding. While reported fusion rates are high, the risk of severe complications should not be overlooked. Further large clinical trials are required to elucidate whether the CBMs offer any benefits that outweigh the risks.

Keyphrases

low grade
clinical trial
high grade
bone mineral density
soft tissue
bone loss
bone regeneration
postmenopausal women
risk factors
early onset
body composition
case control
phase ii
open label