Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3-eIF3h interaction.

Rui ZhengKe ZhangShanyue TanFang GaoYajie ZhangWenxia XuHuabin WangDongying GuLingjun ZhuShuwei LiHaiyan ChuZhengdong ZhangLingxiang LiuMulong DuMeilin Wang

Published in: Molecular cancer (2022)

This comprehensive study highlights plasma exosomal circLPAR1 as a promising predictor in CRC diagnosis and describes its biological regulation of colorectal tumorigenesis. This study provides a new perspective on early diagnosis in the clinic and pathogenesis in disease development.

Keyphrases

primary care
signaling pathway