Self-assembly/disassembly of giant double-hydrophilic polymersomes at biologically-relevant pH.
Sun Hae Ra ShinPatrick T McAninchIan M HendersonAndrew GomezAdrienne C GreeneEric C CarnesWalter F PaxtonPublished in: Chemical communications (Cambridge, England) (2018)
Self-assembled giant polymer vesicles prepared from double-hydrophilic diblock copolymers, poly(ethylene oxide)-b-poly(acrylic acid) (PEO-PAA) show significant degradation in response to pH changes. Because of the switching behavior of the diblock copolymers at biologically-relevant pH environments (2 to 9), these polymer vesicles have potential biomedical applications as smart delivery vehicles.