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The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cells.

Nathalia Azevedo PortilhoDeepak SainiIshtiaque HossainJacinthe SiroisChristopher MoraesWilliam A Pastor
Published in: Epigenetics & chromatin (2021)
GSK-3484862 mediates striking demethylation in mESCs with minimal non-specific toxicity.
Keyphrases
  • embryonic stem cells
  • pi k akt
  • signaling pathway
  • dna methylation
  • oxidative stress
  • gene expression