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Synthesis of novel glycerol-fluorinated triazole derivatives and evaluation of their phytotoxic and cytogenotoxic activities.

Fernando Fontes BarcelosThammyres de Assis AlvesPoliana Aparecida Rodrigues GazollaVanessa Carla Furtado MosqueiraVagner Tebaldi de QueirozMilene Miranda Praça FontesPedro Alves Bezerra MoraisVictor R FonsecaWanderson RomãoValdemar Lacerda JúniorRodrigo SchererAdilson Vidal Costa
Published in: Anais da Academia Brasileira de Ciencias (2023)
The control of weeds in agriculture is mainly conducted with the use of synthetic herbicides. However, environmental and human health concerns and increased resistance of weeds to existing herbicides have increased the pressure on researchers to find new active ingredients for weed control which present low toxicity to non-target organisms, are environmentally safe, and can be applied at low concentrations. It is herein described the synthesis of glycerol-fluorinated triazole derivatives and evaluation of their phytotoxic and cytogenotoxic activities. Starting from glycerol, ten fluorinated triazole derivatives were prepared in four steps. The assessment of them on Lactuca sativa revealed that they present effects on phytotoxic and cytogenotoxic parameters with different degrees of efficiency. The compounds 4a, 4b, 4d, 4e, 4i, and 4j have pre-emergent inhibition behavior, while all the investigated compounds showed post emergent effect. Mechanism of action as clastogenic, aneugenic, and epigenetic were observed in the lettuce root meristematic cells, with alterations as stick chromosome, bridge, delay, c-metaphase, and loss. It is believed that glycerol-fluorinated triazole derivatives possess a scaffold that can be explored towards the development of new chemicals for the control of weed species.
Keyphrases
  • human health
  • risk assessment
  • climate change
  • structure activity relationship
  • induced apoptosis
  • gene expression
  • cell cycle arrest
  • single cell
  • endoplasmic reticulum stress
  • cell proliferation
  • life cycle