Hoechst-tagged radioiodinated BODIPY derivative for Auger-electron cancer therapy.

Ryotaro OnoueHiroyuki Watanabe Masahiro Ono

Published in: Chemical communications (Cambridge, England) (2023)

Targeted radionuclide therapy using Auger electrons is a promising strategy in cancer treatment. A DNA-binding Hoechst-tagged radioiodinated BODIPY derivative ([ 125 I]BH) has been prepared as an Auger therapeutic agent. [ 125 I]BH showed high accumulation in the nucleus of HeLa cells and cytotoxicity caused by DNA double-strand breaks.

Keyphrases

cancer therapy
dna binding
cell cycle arrest
fluorescent probe
induced apoptosis
living cells
drug delivery
transcription factor
cell death
circulating tumor
single molecule
pi k akt
cell free
endoplasmic reticulum stress
cell proliferation
replacement therapy