ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta-analysis.

Leila KarimiSusanne J VijverbergMarjolein EngelkesNatalia Hernandez-PachecoNiloufar FarzanPatricia Soares Maria Pino-YanesAndrea L JorgensenCeleste EngSomnath MukhopadhyayMaximilian SchieckMichael KabeschEsteban G BurchardFook Tim ChewYang Yie SioUroš PotočnikMario GorenjakDaniel B HawcuttColin N PalmerStephen W TurnerHettie M JanssensAnke H Maitland-van der ZeeKatia M C Verhammenull null

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2021)

The ADRB2 Arg16 haplotype, presumably mainly driven by the Arg16, increased the risk of asthma exacerbations in patients treated with ICS plus LABA. This finding could be beneficial in ADRB2 genotype-guided treatment which might improve clinical outcomes in asthmatic patients.

Keyphrases

chronic obstructive pulmonary disease
young adults
lung function
systematic review
cystic fibrosis
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
allergic rhinitis
electronic health record
big data
air pollution
data analysis