Profiling people with Parkinson's disease at risk of cognitive decline: Insights from PPMI and ICICLE-PD data.

Dana PourzinalRachael A LawsonAlison J YarnallCaroline H Williams-GrayRoger A BarkerJihyun YangKatie L McMahonJohn D O'SullivanGerard J ByrneNadeeka N W Dissanayaka

Published in: Alzheimer's & dementia (Amsterdam, Netherlands) (2024)

Four cognitive subtypes were revealed in two Parkinson's disease samples.Unique profiles of cognitive impairment were related to cognitive decline.Judgement of Line Orientation/category fluency predictive of steady decline.Global deficits related to rapid cognitive decline and increased dementia risk.

Keyphrases

cognitive decline
mild cognitive impairment
cognitive impairment
single cell
traumatic brain injury
big data
data analysis
drug induced