Cholestane-3β,5α,6β-Triol Inhibits Acid-Sensing Ion Channels and Reduces Acidosis-Mediated Ischemic Brain Injury.

Huawei SunTao YangRoger SimonZhi-Gang Xiong Tiandong Leng

Published in: Stroke (2024)

Our study identifies Triol as a novel ASIC inhibitor, which may serve as a new pharmacological tool for studying ASICs and may also be developed as a potential drug for treating stroke.

Keyphrases

brain injury
cerebral ischemia
subarachnoid hemorrhage
atrial fibrillation
genome wide
gene expression
oxidative stress
climate change