Cytoplasmic localization of connexin 26 suppresses transition of β-catenin into the nucleus in intestinal- and mix-type gastric cancer.

Nobuhiro Nakazawa Makoto Sohda Takehiko Yokobori Navchaa Gombodorj Akihiko Sano Makoto Sakai Tetsunari Oyama Hiroyuki Kuwano Ken Shirabe Hiroshi Saeki

Published in: Annals of gastroenterological surgery (2022)

Cytoplasmic Cx26 was found to be a prognostic factor in intestinal- and mix-type gastric cancer. Regarding the mechanism, in vitro studies revealed that cytoplasmic Cx26 inhibits the translocation of β-catenin to the nucleus.

Keyphrases

prognostic factors
epithelial mesenchymal transition
cell proliferation
signaling pathway
case control