Near-infrared Light-Enhanced Generation of Hydroxyl Radical for Cancer Immunotherapy.

Hydroxyl radical (•OH) as a highly oxidizing reactive oxygen species (ROS) can induce immunogenic cell death (ICD) in cancer treatment. However, high-efficiency cancer immunotherapy is still a huge challenge due to the low •OH generation efficiency in the tumor microenvironment (TME), resulting in insufficient immunogenicity and the poor immune response. Here, we developed a near-infrared (NIR) light-enhanced •OH generation strategy for cancer immunotherapy by using a copper-based metal-organic framework (Cu-DBC) nanoplatform. With this strategy, the generation efficiency of •OH under NIR irradiation was increased 7.34 times than that without NIR irradiation, which induced robust ICD and immune response, thus leading to primary tumor elimination and the inhibition of distant tumor growth and tumor lung metastasis. Experimental results showed that Cu-DBC could induce •OH boosting through photothermal (PT)-enhanced Cu-catalytic Fenton-like reaction and photocatalytic electron transfer under NIR light irradiation to amplify tumor ICD for immunotherapy. This article is protected by copyright. All rights reserved.