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LiHMDS-Promoted Palladium-Catalyzed Sonogashira Cross-Coupling of Aryl Fluorides with Terminal Alkynes.

Jingjing HeKang YangJianhong ZhaoSong Cao
Published in: Organic letters (2019)
A highly efficient Pd-catalyzed Sonogashira coupling of various aryl fluorides with terminal alkynes in the presence of LiHMDS was developed. Both unreactive electron-rich fluoroarenes and electron-poor fluoroarenes proceeded smoothly and afforded the corresponding internal alkynes in moderate to excellent yields.
Keyphrases
  • highly efficient
  • room temperature
  • electron transfer
  • solar cells
  • electron microscopy