The STING antagonist H-151 ameliorates psoriasis via suppression of STING/NF-κB-mediated inflammation.

Yanhong PanYanping YouLi SunQibang SuiLiu LiuHaoliang YuanCaiping ChenJun LiuXiaoan WenLiang DaiHong-Bin Sun

Published in: British journal of pharmacology (2021)

H-151 displayed anti-inflammatory activity in both keratinocytes and immune cells, and decreased the severity of psoriatic response in vivo. Inhibition of STING signalling pathway may represent a novel therapeutic approach to psoriasis and related complications.

Keyphrases

oxidative stress
signaling pathway
rheumatoid arthritis
ankylosing spondylitis
disease activity
risk factors
mouse model
pi k akt
nuclear factor
systemic lupus erythematosus
cell proliferation
toll like receptor