A chitosan grafted mesoporous carbon aerogel for ultra-sensitive voltammetric determination of isoniazid.
Chellakannu RajkumarRaja NehruShen Ming ChenS Arumugamnull Qin-JinYeahRaman SankarPublished in: Mikrochimica acta (2019)
A screen-printed carbon electrode (SPCE) was modified with chitosan (Chit) supported on carbon aerogel (CA) to obtain an electrochemical sensor for the tuberculosis drug isoniazid (INZ). The interconnected mesoporous structure of Chit/CA provides a large surface area (SBET = 461 m2 g-1) and good porosity (VTot = 0.69 cm3 g-1). Besides, the modified SPCE displayed enhanced electrocatalytic activity due to the presence of numerous active sites (such as >C=O, -NH-, -NH2, -OH). Figures of merit include (a) a typical working voltage of 0.28 V (vs. Ag/AgCl), (b) high sensitivity (8.09 μA μM-1 cm-2), (c) a wide linear response to INZ (0.01-115 μM) and (d) a low detection limit (8 nM). The modified electrode has successfully been applied to the determination of INZ in spiked serum and urine, and recoveries ranged from 97.8 to 99.8%. Graphical abstract Schematic illustration of preparation and applications of a nanocomposite consisting of chitosan (Chit; CS) supported on carbon aerogel (CA) for electrochemical detection of isoniazid.
Keyphrases
- reduced graphene oxide
- molecularly imprinted
- mycobacterium tuberculosis
- gold nanoparticles
- drug delivery
- solid phase extraction
- label free
- wound healing
- room temperature
- carbon nanotubes
- hyaluronic acid
- highly efficient
- metal organic framework
- ionic liquid
- real time pcr
- quantum dots
- protein kinase
- pulmonary tuberculosis
- photodynamic therapy
- loop mediated isothermal amplification
- emergency department
- hiv aids
- simultaneous determination
- hepatitis c virus
- human immunodeficiency virus
- hiv infected
- adverse drug
- visible light
- electron transfer