Lysyl oxidase like 2 is increased in asthma and contributes to asthmatic airway remodelling.
Jopeth RamisRobert MiddlewickFrancesco PappalardoJennifer T CairnsIain D StewartAlison E JohnShams-Un-Nisa NaveedRamaswamy KrishnanSuzanne MillerDominick E ShawChristopher E BrightlingLee ButteryFelicity RoseGisli JenkinsSimon R JohnsonAmanda L TatlerPublished in: The European respiratory journal (2022)
These data are the first to highlight a role for LOXL2 in the development of asthmatic airway remodelling and suggest that LOXL2 inhibition warrants further investigation as a potential therapy to reduce remodelling of the airways in severe asthma.