Axonal mRNA transport and translation at a glance.
Pabitra K SahooDeanna S SmithNora I Perrone-BizzozeroJeffery L TwissPublished in: Journal of cell science (2018)
Localization and translation of mRNAs within different subcellular domains provides an important mechanism to spatially and temporally introduce new proteins in polarized cells. Neurons make use of this localized protein synthesis during initial growth, regeneration and functional maintenance of their axons. Although the first evidence for protein synthesis in axons dates back to 1960s, improved methodologies, including the ability to isolate axons to purity, highly sensitive RNA detection methods and imaging approaches, have shed new light on the complexity of the transcriptome of the axon and how it is regulated. Moreover, these efforts are now uncovering new roles for locally synthesized proteins in neurological diseases and injury responses. In this Cell Science at a Glance article and the accompanying poster, we provide an overview of how axonal mRNA transport and translation are regulated, and discuss their emerging links to neurological disorders and neural repair.
Keyphrases
- single cell
- spinal cord injury
- induced apoptosis
- transcription factor
- stem cells
- optic nerve
- public health
- high resolution
- rna seq
- spinal cord
- cell cycle arrest
- gene expression
- genome wide
- oxidative stress
- quality improvement
- cerebral ischemia
- bone marrow
- endoplasmic reticulum stress
- cell death
- signaling pathway
- brain injury
- liquid chromatography
- nucleic acid
- single molecule
- photodynamic therapy
- peripheral nerve