Comparative clinical efficacy and safety of insulin glargine 300 U/ml (Toujeo) versus insulin glargine 100 U/ml in type 2 diabetes and type 1 diabetes: A systematic literature review and meta-analysis.

Shashank R JoshiGursharan SinghAshwani MarwahShivani MittraViraj R SuvarnaSandeep N Athalye

Published in: Diabetes, obesity & metabolism (2023)

Gla-100 and Gla-300 had comparable efficacy and safety profiles in both T1D and T2D populations. Gla-300 showed a lower risk of nocturnal and total hypoglycaemia, significant in insulin-experienced/exposed patients with T2D. Patients on Gla-300 required significantly more units of insulin daily than the Gla-100 group to achieve equivalent efficacy.

Keyphrases

type diabetes
glycemic control
end stage renal disease
cardiovascular disease
insulin resistance
ejection fraction
chronic kidney disease
newly diagnosed
obstructive sleep apnea
physical activity
prognostic factors
weight loss
peritoneal dialysis
adipose tissue
metabolic syndrome
patient reported outcomes