Monitoring the three-dimensional distribution of endogenous species in the lungs by matrix-assisted laser desorption/ionization mass spectrometry imaging.
Bryn FlindersJosie MorrellPeter S MarshallLisa E RanshawRon M A HeerenMalcolm R ClenchPublished in: Rapid communications in mass spectrometry : RCM (2021)
A straightforward method to generate 3D MALDI-MS images of selected molecules in lung tissue has been presented. Using freely available imaging software, the 3D distributions of molecules related to different anatomical features were determined.