OX2 receptors mediate the inhibitory effects of orexin-A on potassium chloride-induced increases in intracellular calcium ion levels in neurons derived from rat dorsal root ganglion in a chronic pain model.

The present findings constitute neuropharmacological evidence that OX2 but not OX1 receptors mediate the inhibitory effects of orexin-A on KCl-induced increases in [Ca2+ ]i in C-fiber-like neurons of rats showing hyperalgesia provoked by sciatic nerve ligation.