Integrated DNA and RNA Sequencing Reveals Drivers of Endocrine Resistance in Estrogen Receptor-Positive Breast Cancer.

Youli XiaXiaping HeLorna RenshawCarlos Martinez-Perez Charlene Kay Mark E Gray James Meehan Joel S Parker Charles M Perou Lisa Anne CareyJ Michael DixonArran K Turnbull

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

The mechanisms underlying ETR are multiple and characterized by diverse changes in both somatic genetic and transcriptomic profiles; to overcome resistance will require an individualized approach utilizing genomic and genetic biomarkers and drugs tailored to each patient.

Keyphrases

estrogen receptor
positive breast cancer
copy number
single cell
genome wide
case report
single molecule
cell free
smoking cessation
gene expression
drug induced