O-GlcNAcylated LARP1 positively regulated by circCLNS1A facilitates hepatoblastoma progression through DKK4/β-catenin signalling.

Zhongqi CuiJiangtu HeJiabei ZhuWenxuan NiLi LiuZhixuan BianSiwei MaoSong GuYuhua ShanZhexuan ChuQi WuJiayi LuYa LiuFenyong SunQiuhui PanYue ZhangNan HuangJi Ma

Published in: Clinical and translational medicine (2023)

This study indicates that upregulated protein level of O-GlcNAcylated LARP1 mediated by circCLNS1A promotes the tumorigenesis and progression of HB through LARP1/DKK4/β-catenin axis. Hence, LARP1 and DKK4 are promising therapeutical target and diagnostic/prognostic plasma biomarker for HB.

Keyphrases

epithelial mesenchymal transition
cell proliferation
amino acid
small molecule
binding protein