The PDZ-Binding Motif of HPV16-E6 Oncoprotein Modulates the Keratinization and Stemness Transcriptional Profile In Vivo.

Enoc Mariano Cortés-MalagónCarmen Palacios-ReyesSandra Romero-CordobaDaniel Mendoza-VillanuevaJaime Escobar-HerreraOdette Verdejo-TorresRubén Gerardo ContrerasGloria Fernádez-TilapaMario Adán Moreno-EutimioJosé MorenoAlfredo Hidalgo-MirandaPatricio Gariglio José Bonilla-Delgado

Published in: BioMed research international (2017)

The E6 PDZ-binding motif appears to affect stemness and keratinization during early stages of skin carcinogenesis. As E6 plays a significant role in HPV-induced skin carcinogenesis, the K14E6 versus K14E6Δ146-151 transcriptional profile provides a source of valuable data to uncover novel E6 functions in the skin.

Keyphrases

soft tissue
stem cells
wound healing
epithelial mesenchymal transition
gene expression
high grade
transcription factor
electronic health record
binding protein
high glucose
heat shock
machine learning
big data
cancer stem cells
drug induced
cervical cancer screening