A severe asthma phenotype of excessive airway Haemophilus influenzae relative abundance associated with sputum neutrophilia.

Ali VersiAdnan AzimFransiskus Xaverius IvanMahmoud I Abdel-AzizStewart BatesJohn RileyMohib UddinNazanin Zounemat KermaniAnke-H Maitland-Van Der ZeeSven-Eric DahlenRatko DjukanovicSanjay H ChotirmallPeter HowarthIssssswan M Adcock Kian Fan Chungnull null

Published in: Clinical and translational medicine (2024)

We describe a Haemophilus influenzae cluster of the highest relative abundance associated with neutrophilic inflammation and NETosis indicating a host response to the bacteria. This phenotype of severe asthma may respond to specific antibiotics.

Keyphrases

antibiotic resistance genes
oxidative stress
cystic fibrosis
mycobacterium tuberculosis
pulmonary tuberculosis
weight gain
microbial community
wastewater treatment
body mass index
physical activity
weight loss
anaerobic digestion