A Novel Mouse Model of Acute-on-Chronic Cholestatic Alcoholic Liver Disease: A Systems Biology Comparison With Human Alcoholic Hepatitis.

Shinji FuruyaJosepmaria ArgemiTakeki UeharaYuuki KatouDerrick E FoutsBernd SchnablLaurent DubuquoyAbha BelorkarRajanikanth VadigepalliHiroshi KonoRamon BatallerIvan Rusyn

Published in: Alcoholism, clinical and experimental research (2019)

We developed a novel mouse model of acute-on-chronic cholestatic alcoholic liver injury that has considerable translational potential and can be used to test novel therapeutic modalities for AH.

Keyphrases

liver injury
drug induced
mouse model
liver failure
respiratory failure
intensive care unit
human health
mechanical ventilation
liver fibrosis